Acute Myocardial Infarction Following Carboplatin Therapy in a Patient with Nasopharyngeal Carcinoma: A Case Report

Abstract

Platinum-based chemotherapy agents such as carboplatin have been associated with rare but severe adverse cardiac events, including myocardial infarction (MI). Nasopharyngeal carcinoma (NPC), which responds well to chemoradiotherapy, presents unique cardiovascular challenges due to cancer-induced inflammation and thrombosis. We present the case of a 65-year-old woman with stage III NPC who developed acute inferolateral MI during concurrent carboplatin-based chemoradiotherapy. She presented with severe chest pain, ST elevation on ECG, and elevated troponin levels. Coronary angiography revealed multiple vesels disease, and prompt percutaneous coronary intervention (PCI) was performed. This case highlights the need for vigilance during carboplatin therapy, especially in high-risk patients. Cardiovascular screening and monitoring should be integrated into clinical care. Carboplatin-induced MI through multiple mechanisms, including direct myocardial injury, vascular disturbances, and electrolyte imbalances.